Veröffentlichungen

Abstract:

Tissue heating during magnetic resonance measurements is a potential hazard at high-field MRI, and particularly, in the framework of parallel radiofrequency transmission. The heating is directly related to the radiofrequency energy absorbed during an magnetic resonance examination, that is, the specific absorption rate (SAR). SAR is a pivotal parameter in MRI safety regulations, requiring reliable estimation methods. Currently used methods are usually based on models which are neither patient-specific nor taken into account patient position and posture, which typically leads to the need for large safety margins. In this work, a novel approach is presented, which measures local SAR in a patient-specific manner. Using a specific formulation of Maxwell's equations, the local SAR is estimated via postprocessing of the complex transmit sensitivity of the radiofrequency antenna involved. The approximations involved in the proposed method are investigated. The presented approach yields a sufficiently accurate and patient-specific local SAR measurement of the brain within a scan time of less than 5 min.

Abstract:

The electric properties of human tissue can potentially be used as an additional diagnostic parameter, e.g., in tumor diagnosis. In the framework of radiofrequency safety, the electric conductivity of tissue is needed to correctly estimate the local specific absorption rate distribution during MR measurements. In this study, a recently developed approach, called electric properties tomography (EPT) is adapted for and applied to in vivo imaging. It derives the patient's electric conductivity and permittivity from the spatial sensitivity distributions of the applied radiofrequency coils. In contrast to other methods to measure the patient's electric properties, EPT does not apply externally mounted electrodes, currents, or radiofrequency probes, which enhances the practicability of the approach. This work shows that conductivity distributions can be reconstructed from phase images and permittivity distributions can be reconstructed from magnitude images of the radiofrequency transmit field. Corresponding numerical simulations using finite-difference time-domain methods support the feasibility of this phase-based conductivity imaging and magnitude-based permittivity imaging. Using this approximation, three-dimensional in vivo conductivity and permittivity maps of the human brain are obtained in 5 and 13 min, respectively, which can be considered a step toward clinical feasibility for EPT. Magn Reson Med, 2011. (c) 2011 Wiley-Liss, Inc.

Abstract:

This work presents a new approach toward a fast, simultaneous amplitude of radiofrequency field (B(1)) and T(1) mapping technique. The new method is based on the "actual flip angle imaging" (AFI) sequence. However, the single pulse repetition time (TR) pair used in the standard AFI sequence is replaced by multiple pulse repetition time sets. The resulting method was called "multiple TR B(1)/T(1) mapping" (MTM). In this study, MTM was investigated and compared to standard AFI in simulations and experiments. Feasibility and reliability of MTM were proven in phantom and in vivo experiments. Error propagation theory was applied to identify optimal sequence parameters and to facilitate a systematic noise comparison to standard AFI. In terms of accuracy and signal-to-noise ratio, the presented method outperforms standard AFI B(1) mapping over a wide range of T(1). Finally, the capability of MTM to determine T(1) was analyzed qualitatively and quantitatively, yielding good agreement with reference measurements. Magn Reson Med, 2010. (c) 2010 Wiley-Liss, Inc.

Abstract:

The electric conductivity can potentially be used as an additional diagnostic parameter, e.g., in tumour diagnosis. Moreover, the electric conductivity, in connection with the electric field, can be used to estimate the local SAR distribution during MR measurements. In this study, a new approach, called electric properties tomography (EPT) is presented. It derives the patient's electric conductivity, along with the corresponding electric fields, from the spatial sensitivity distributions of the applied RF coils, which are measured via MRI. Corresponding numerical simulations and initial experiments on a standard clinical MRI system underline the principal feasibility of EPT to determine the electric conductivity and the local SAR. In contrast to previous methods to measure the patient's electric properties, EPT does not apply externally mounted electrodes, currents, or RF probes, thus enhancing the practicability of the approach. Furthermore, in contrast to previous methods, EPT circumvents the solution of an inverse problem, which might lead to significantly higher spatial image resolution.

Abstract:

The electric conductivity of human tissue could be used as an additional diagnostic parameter or might be helpful for the prediction of the local SAR during MR measurements. In this study, the approach Electric Properties Tomography (MR-EPT) is applied, which derives the patients electric conductivity using a standard MR system. To this goal, the spatial transmit sensitivity distribution of the applied RF coil is measured. This sensitivity distribution represents the positive circularly polarized component of the magnetic field. It can be post-processed utilizing Faradays and Amperes law, yielding an estimation of the spatial distribution of the patients electric conductivity. Thus, MR-EPT does not apply externally mounted electrodes, currents, or RF probes. In this study, phantom experiments underline the principle feasibility of MR-EPT. Furthermore, initial conductivity measurements in the brain allow distinguishing cerebrospinal fluid from the surrounding grey and white matter.

Abstract:

The electrical conductivity of human tissue could be used as an additional diagnostic parameter or might be helpful for the prediction of the local SAR during MR measurements. In this study, the approach "Electric Properties Tomography" (EPT) is applied, which derives the patient's electric conductivity using a standard MR system. To this goal, the spatial transmit sensitivity distribution of the applied RF coil is measured. This sensitivity distribution represents the positive circularly polarized component of the magnetic field. It can be post-processed utilizing Faraday's and Ampere's law, yielding an estimation of the spatial distribution of the patient's electric conductivity. Thus, EPT does not apply externally mounted electrodes, currents, or RF probes. In this study, phantom experiments underline the principle feasibility of EPT. Furthermore, initial conductivity measurements in the brain allow distinguishing cerebro-spinal fluid from the surrounding grey and white matter.