GRS/GRC 2025 in Barga

The Gordon Research Seminar and Conference on Cardiac Arrhythmia Mechanisms were held in Barga from February 22 to 27.

Within almost one week, a wide range of topics was covered, from atrial and ventricular mechanisms to micro- and ultrastructures of individual cardiac muscle cells. Additionally, gender-specific differences, co-morbidities, and therapeutic strategies were discussed. Christian, Moritz and Axel (on behalf of Tobias) took the opportunity to present their work. Based on experimental and simulative data, Christian presented the antiarrhythmic effect of Etripamil, which is already a known drug and has the potential to be used in the future in atrial fibrillation therapy for cardioversion of arrhythmias. Moritz explored interspecies differences between the extended Severi (rabbit) and Fabbri (human) sinoatrial node cell models to elucidate the pathophysiological mechanisms of the elevated prevalence of sudden cardiac death in haemodialysis patients, and Axel showed the differential effects of mechano-electric feedback in whole-heart activation, repolarisation, and tension.